GlycoNoVi – Understanding the Role of Glycans in Human Norovirus Infection: a Key to Unlock New Therapies, is a Marie Skłodowska-Curie European Doctorate Network (EDN) funded by the European Commission (Grant agreement no: 101072717).
Glycans are carbohydrate structures ubiquitously found on the surface of cells and take part in many biological processes, including cell signaling and neoplasia. Research on glycans is challenging in part due to the limited availability of biologically relevant synthetic glycans and to technical challenges in the analysis of glycan-protein interactions. Glycans also exhibit key roles in viral infections, mediating virus attachment and entry. Human noroviruses (NoVs) are the major cause of viral gastroenteritis and foodborne illnesses causing morbidity, mortality and economic losses. NoV infections are self-limiting in healthy individuals but are associated with severe complications in immunocompromised individuals, the elderly and young children. In addition, frequently occurring new NoV genotypes and variants can cause large outbreaks and epidemics worldwide. Very little is known about NoV infections in most non-human hosts and the close genetic similarities between some animal and human NoVs leads to the realistic hypothesis that the virus might jump the species barrier triggering pandemic variants. Importantly, no therapy is currently available to treat or prevent NoV infections. The requirement for NoVs to attach to specific glycans to infect hosts’ tissues, and cells, has been well established but the underlying mechanisms remain to be elucidated.
Going beyond the state-of-the-art, the overall aims of GlycoNoVi is training 10 researchers to address knowledge gaps on NoV glycan interactions and investigate the exciting possibility of developing synthetic glycans as antiviral strategies to treat NoV infection. [DC2 position will be directly founded by UK and not by EU].
These aims will be achieved bringing together 5 academic and 3 industrial leaders in glycoscience, glycovirology and NoV field and relying on a multidisciplinary and interconnected approach which is declinate in research-oriented WP1-5 and WP6-8 focused respectively on training, outreach and coordination.
UNIVERSITA DEGLI STUDI DI FIRENZE (UNIFI) – Italy
REACT4LIFE SRL (R4L) – Italy
INBIOSE NV (INBIOSE NV) – Belgium
GLYCOM AS (GLYCOM AS) – Denmark
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS (CNRS) – France
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, M.P. (CSIC) – Spain
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM (EMC) – Netherlands
UNIVERSITAET ZU LUEBECK (UZL) – Germany
DIAGNOSTICS LIMITED, UK (ICENI) – United Kingdom
GHENT UNIVERSITY (UGent) – Belgium
DANMARKS TEKNISKE UNIVERSITET, Demark (DTU) – Denmark
UNIVERSITE’ GRENOBLE ALPES (UGA) – France
UNIVERSIDAD DE SEVILLA, ES (USE) – Spain
THE UNIVERSITY OF MANCHESTER, UK (UMAN) – United Kingdom
UNIVERSITA’ DEGLI STUDI DI MILANO-BICOCCA, IT (UNIMB) – Italy
1-8 – Beneficiaries
9-14 – Associated Partners
This project has received funding from the European Union’s Horizon Research and Innovation programme under the Marie Skłodowska-Curie (HORIZON-MSCA-2021-DN-01) grant agreement No. 101072717.