Synthesis of selected HMOs

Hiring institution:

Glycom (DSM)




Kogle Alle 4, 2970 Hørsholm



Reference contact:

dr. Dora Molnar Gabor

email: dora.molnar-gabor@dsm.com

Research field:

Chemical synthesis of complex carbohydrates, e.g. Human milk oligosaccharides (HMOs)

Project description:

Enrolment in Doctoral degree at DTU (Danish Technical University)

Objectives: Research: 1) Set up selection criteria for HMO and HMOs analogues structures of interest based on literature and in silico evaluation; 2) Develop novel synthetic routes for the selected structures; 3) scale-up the synthesis of relevant and unavailable HMOs to g scale; 4) Characterize the novel products by NMR and LCMS techniques. 

Training: Experience in: 1) in silico modelling, chemical synthesis of complex carbohydrates and structure character.; 2) NMR and LCMS techniques.

Planned secondment(s): 1) University of Sevilla, 3 months, focus on glycan screening; 2) University of Firenze, 3 months, thio-glycosylation experience

Elegibility criteria:

You should not have resided or carried out your main activity (work, studies, etc.) in Denmark for more than 12 months in the last 3 years.

No previous PhD.

Required education level:

Chemistry: Master Degree or equivalent

Required languages: 

ENGLISH: Good (demonstrated by TOFL or similar)

Other requirements: 

Experience with synthetic carbohydrate chemistry is an advantage (not a requirement)

This project has received funding from the European Union’s Horizon Research and Innovation programme under the Marie Skłodowska-Curie (HORIZON-MSCA-2021-DN-01) grant agreement No. 101072717.